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Chapter 26: Problem 9
Describe the events that occur at a synapse when a neural impulse arrives at asynaptic terminal of a presynaptic cell.
Short Answer
Expert verified
Neural impulse causes Ca²⁺ influx, triggering neurotransmitter release, which binds to postsynaptic receptors, generating a synaptic response.
Step by step solution
01
- Arrival of the Neural Impulse
When a neural impulse (action potential) arrives at the synaptic terminal of the presynaptic cell, it causes the depolarization of the presynaptic membrane.
02
- Opening of Voltage-Gated Calcium Channels
The depolarization opens voltage-gated calcium (Ca²⁺) channels in the presynaptic membrane, allowing Ca²⁺ ions to enter the synaptic terminal.
03
- Neurotransmitter Release
The influx of Ca²⁺ ions causes synaptic vesicles filled with neurotransmitters to merge with the presynaptic membrane and release their contents into the synaptic cleft.
04
- Binding to Receptors
Neurotransmitters diffuse across the synaptic cleft and bind to specific receptors on the postsynaptic membrane.
05
- Postsynaptic Response
The binding of neurotransmitters to receptors on the postsynaptic cell can result in either excitatory postsynaptic potentials (EPSPs) or inhibitory postsynaptic potentials (IPSPs), depending on the type of neurotransmitter and receptor involved.
06
- Termination of Signal
The signal is terminated when neurotransmitters are either reabsorbed by the presynaptic cell, degraded by enzymes, or diffuse away from the synaptic cleft.
Key Concepts
These are the key concepts you need to understand to accurately answer the question.
Neural Impulse
A neural impulse, also known as an action potential, is the way nerve cells communicate. It is a brief electrical charge that travels down the axon of a neuron. This process begins when the neuron receives a sufficient stimulus, causing a change in electrical charge across its membrane.
Neurons maintain a resting membrane potential due to differences in ion concentrations inside and outside the cell. When an action potential happens, there is a rapid depolarization of the membrane.
The change in electrical charge along the neuron helps transmit signals quickly along the nervous system. When this impulse reaches the end of the neuron, it causes various events in the synaptic terminal, leading to neurotransmitter release.
Synaptic Terminal
The synaptic terminal is the endpoint of a neuron where the communication with another cell occurs. It's packed with synaptic vesicles, which are tiny sacs containing neurotransmitters—the chemicals responsible for transmitting signals across the synapse.
When a neural impulse reaches the synaptic terminal, it plays a crucial role in converting the electrical signal into a chemical signal. This conversion is essential for the communication between neurons and between neurons and other types of cells.
The presynaptic membrane of the synaptic terminal is responsible for the release of neurotransmitters into the synaptic cleft, a small gap separating the presynaptic neuron from the postsynaptic cell.
Neurotransmitter Release
Neurotransmitter release is a key event that occurs after a neural impulse arrives at the synaptic terminal. The arrival of the action potential causes depolarization of the presynaptic membrane, leading to the opening of voltage-gated calcium channels.
Calcium ions (Ca²⁺) flow into the presynaptic cell, which is the driving force behind the synaptic vesicles merging with the membrane. This process, known as vesicle fusion, releases neurotransmitters into the synaptic cleft.
Released neurotransmitters then diffuse across the synaptic cleft and bind to receptors on the membrane of the postsynaptic cell, triggering further cellular responses.
Calcium Channels
Calcium channels are vital proteins located in the membrane of the presynaptic terminal. They are sensitive to changes in voltage and are specifically designed to allow Ca²⁺ ions to pass through.
When an action potential reaches the synaptic terminal, it causes the depolarization of the presynaptic membrane, prompting these voltage-gated calcium channels to open.
This opening allows calcium ions to rush into the synaptic terminal's interior. The influx of calcium ions is critical because it signals synaptic vesicles to merge with the presynaptic membrane and release neurotransmitters.
- This release is the magic behind synaptic communication.
Calcium channels thus act as gatekeepers, controlling the entry of calcium ions and thus the release of neurotransmitters.
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